Clinical Edge

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Hippocampal Sparing Temporal Lobectomy Recommended for Medically Refractory Epilepsy

Key clinical point: Sparing the hippocampus during anterior temporal lobectomy for refractory epilepsy – so long as it’s normal on imaging, with no sign of mesial temporal sclerosis – reduces memory loss without affecting the procedure’s efficacy.

Major finding: Standard temporal lobectomy had a slight edge early on, but at 2 years, about 62% of patients in both groups were seizure free. At 5 years, about 50% were seizure free, and almost 40% in both arms at 7.5 years.

Study details: Case-control comparison involving 40 patients

Disclosures: There was no external funding, and the senior investigator had no relevant disclosures.


Goldstein L et al. AES 2019, Abstract 1.339.