Clinical Edge

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Antiepileptic Drugs May Not Independently Impair Cognition

Key clinical point: Antiepileptic drug therapy is not associated with impairments in objective or subjective cognitive function above other clinically relevant factors.

Major finding: Increasing seizure frequency was associated with objective cognitive dysfunction, and depression was associated with subjective cognitive impairment.

Study details: A cross-sectional analysis of 331 prospectively enrolled patients who were admitted to a video EEG monitoring unit.

Disclosures: The study was conducted without external funding. Dr. Foster and other investigators reported research funding from professional associations and pharmaceutical companies that was unrelated to the study.


Foster E et al. Neurology. 2020 Feb 3. doi: 10.1212/WNL.0000000000009061.