Clinical Edge

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AED Exposure From Breastfeeding Appears to be Low

Key clinical point: AED concentrations in infants who were breastfed are lower than maternal concentrations.

Major finding: The median percentage of infant-to-mother concentration for seven AEDs ranged from 0.3% to 44.2%.

Study details: An analysis of data from the prospective Maternal Outcomes and Neurodevelopmental Effects of AEDs study.

Disclosures: The National Institute of Neurological Disorders and Stroke and the National Institute of Child Health and Development funded the research. The authors reported receiving research support from various pharmaceutical companies.


Birnbaum AK et al. JAMA Neurol. 2019 Dec 30. doi: 10.1001/jamaneurol.2019.4443.