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Tight blood pressure control fails to reduce dementia risk in hypertensive adults

Key clinical point: Intensive blood pressure control had no significant impact on reducing dementia risk in adults with hypertension.

Major finding: The probable dementia rates among adults with hypertension who were randomized to blood pressure targets of less than 120 mm Hg and less than 140 mm Hg were, respectively, 7.2 and 6.8 cases per 1,000 person-years.

Study details: The data come from a randomized trial of 9,361 adults with hypertension.

Disclosures: The study was supported by the National Heart, Lung, and Blood Institute, the National Institute of Diabetes and Digestive and Kidney Diseases, the National Institute on Aging, and the National Institute of Neurological Disorders and Stroke, as well as the Department of Veterans Affairs and the Intramural Research Program of the National Institute on Aging. Medications were provided by Takeda Pharmaceuticals. Additional funding was provided by the Kulynych Family Foundation, and the Oristano Family Foundation as well as research awards from the National Center for Advancing Translational Sciences to Case Western Reserve University; Ohio State University; University of Pennsylvania; Stanford University; Tufts Medical Center; University of Illinois; University of Pittsburgh; University of Texas Southwestern Medical Center; University of Utah; Vanderbilt University; George Washington University; University of California, Davis; University of Florida; University of Michigan; Tulane University; Wake Forest Claude Pepper Center; and Wake Forest University Alzheimer’s Disease Research Center.


Williamson JD et al. JAMA. 2019 Jan 28. doi: 10.1001/jama.2018.21442.