Clinical Edge

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Stress and trauma raise risk for neurodegenerative disease

Key clinical point: Individuals exposed to stress and trauma had a higher risk of developing neurodegenerative diseases compared with unexposed controls.

Major finding: Adults with a stress-related disorder from exposure to stress or trauma were significantly more likely than controls to develop neurodegenerative disease (hazard ratio 1.57) over approximately 5 years’ follow-up.

Study details: The data come from a population-matched and sibling cohort study including 61,748 exposed and 595,335 unexposed individuals in Sweden.

Disclosures: The researchers had no financial conflicts to disclose.


Song H et al. JAMA Neurol. 2020 Mar 9. doi: 10.1001/jamaneurol.2020.0117.