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Optimal blood pressure to protect cognitive function in elderly populations is unknown

Key clinical point: Researchers have identified associations between hypertension in middle age and cognitive decline years later, but the relationship between blood pressure and cognitive function may vary with age. In elderly populations, episodes of hypotension or excessive blood pressure reduction may cause or worsen cognitive decline.

Major finding: Trials of antihypertensive treatment for the prevention of cognitive impairment have been inconclusive. Despite results suggesting benefit in certain populations, physicians should be cautious when treating and reducing blood pressure in elderly frail people and in very elderly patients.

Study details: A review of observational studies and clinical trials related to blood pressure and cognitive function across age groups.

Disclosures: The author had no conflicts of interest.


Sierra C. Front Cardiovasc Med. 2020 Jan 31. doi: 10.3389/fcvm.2020.00005.