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Most patients with idiopathic REM sleep behavior disorder develop other neurodegenerative diseases

Key clinical point: A majority of patients with idiopathic REM sleep behavior disorder went on to develop dementia or parkinsonism.

Major finding: Over an average 3.6 years’ follow-up (4,890 total person-years), 74% of adults with iRBD converted to an overt neurodegenerative syndrome at an overall conversion rate of 6.3% per year.

Study details: The data come from a prospective study of 1,280 adults with idiopathic REM sleep behavior disorder seen at 24 centers.

Disclosures: The study was supported by the Canadian Institute of Health Research, the Weston Foundation, and the Fonds de la Recherche en Sante Quebec. The researchers had no financial conflicts to disclose.

Citation:

Postuma RB et al. Brain. 2019. Mar. doi: https://doi.org/10.1093/brain/awz030.