Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Identifying gene mutations drives treatment and trial design for dementia patients

Key clinical point: Current research in frontotemporal dementia has focused on mutations in the chromosome 9 open reading frame 72 (C9orf72), progranulin (GRN), and microtubule-associated protein tau (MAPT) genes.

Major finding: Behavioral variant frontotemporal dementia is the most common dementia diagnosis among individuals with C9orf72, GRN, and MAPT mutations, and they may be at increased risk for psychiatric disorders including autism spectrum disorders and schizophrenia.

Study details: The data come from a review of current research on frontotemporal dementia.

Disclosures: The review received no outside funding. The researchers had no financial conflicts to disclose.


Greaves CV et al. J Neurol. 2019 May 22. doi: 10.1007/s00415-019-09363-4.