Clinical Edge

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Cutaneous Reaction to AEDs? Think Autoimmune Epilepsy

Key clinical point: Cutaneous reactions to antiepileptic drugs in adults with long-standing treatment-refractory epilepsy suggest an autoimmune etiology for their neurologic disorder.

Major finding: Four of five neuronal autoantibody-positive chronic epilepsy patients had skin reactions to their AEDs.

Study details: The study involved autoantibody testing of 221 consecutive patients with long-standing epilepsy.

Disclosures: The presenter reported having no financial conflicts regarding the study, conducted free of commercial support.


Watanabe N et al. IEC 2019, Abstract P004.