Key clinical point: Mortality associated with neurodegenerative disease is higher, and mortality associated with other causes lower, among former pro soccer players vs. controls.
Major finding: Mortality associated with neurodegenerative disease was 1.7% vs. 0.5% in the players vs. controls (HR adjusted for competing risks of death, 3.45).
Study details: A retrospective cohort study of 7,676 former pro soccer players and 23,028 matched controls.
Disclosures: This study was supported by the Football Association and Professional Footballers’ Association, and by an NHS Research Scotland Career Researcher Fellowship. Dr. Mackay reported having no relevant financial disclosures.
Mackay D et al. N Engl J Med. 2019 Oct 21. doi: 10.1056/NEJMoa1908483.