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Sleep-disordered breathing linked with Alzheimer’s disease biomarkers in cognitively normal older adults

Key clinical point: Sleep-disordered breathing appears to be a risk factor for dementia in older adults.

Major finding: Participants with sleep-disordered breathing had greater amyloid burden, gray-matter volume, metabolism, and perfusion in the posterior cingulate cortex and precuneus.

Study details: A retrospective analysis of 127 patients in a study of cognitive interventions in aging.

Disclosures: The Age-Well randomized clinical trial is part of the Medit-Ageing project and is funded through the European Union’s Horizon 2020 Research and Innovation Program, INSERM, and Fondation d’ Entreprise MMA des Entrepreneurs du Futur. Dr. André reported no conflicts of interest to disclose.


André C et al. JAMA Neurol. 2020 Mar 23. doi: 10.1001/jamaneurol.2020.0311.