Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Poor Gait Precedes Cognitive Decline & Incident Dementia

In a large study cohort, poor performance on several independent gait domains preceded cognitive decline and incident dementia. Researchers summarized 30 gait parameters into 7 mutually independent gait domains and a Global Gait score. Participants underwent follow-up cognitive assessments between 2014 – 2016 and were followed up for incident dementia for 4 years. Among the findings:

  • 4,258 dementia-free participants (median age 67 years, 55% women) from the Rotterdam Study were included.
  • 3 independent gait domains (base of support, pace, and rhythm) and Global Gait were associated with cognitive decline.
  • 2 independent gait domains (pace and variability) and Global Gait were associated with incident dementia.
  • Associations of gait with cognitive decline and incident dementia were only present in individuals who had been cognitively unimpaired at baseline.

Citation:

Darweesh SKL, et al. Quantitative gait, cognitive decline, and incident dementia: The Rotterdam Study. [Published online ahead of print September 9, 2019]. Alzheimer’s & Dementia. doi:10.1016/j.jalz.2019.03.013.