Memory complaints are common in older black and white persons, and relate to cognitive decline, dementia risk, and neurodegenerative pathologies, according to a recent study. A total of 4,015 community‐based persons (28% black; 74% women; mean baseline age = 78 years) were enrolled in 1 of 4 longitudinal cohort studies, and another 2,937 in a population‐based cohort. Researchers found:
- Baseline memory complaints (n=1,310; 33% of 4,015) were associated with lower cognition and faster decline in all domains, during a mean follow‐up of 6 (SD= 2) years.
- Persons with memory complaints had higher dementia risk and odds of pathologic Alzheimer disease, neocortical Lewy bodies, and other neurodegenerative pathologies.
- Results for dementia risk were similar among blacks and whites.
- Among older persons in the population‐based cohort with similar data, the population‐attributable risk for incident dementia due to memory complaints was 14.0% and did not vary between the black and white groups.
Arvanitakis Z, Leurgans SE, Fleischman DA, et al. Memory complaints, dementia, and neuropathology in older blacks and whites. Ann Neurol. 2018;83(4):718-726. doi:10.1002/ana.25189.
This Week's Must Reads
Hospital Readmission After Seizure Discharge, Neurology; ePub 2018 Dec 21; Blank, et al
VP Shunts and Post-Operative Complications Assessed, J Stroke Cerebrovasc Dis; ePub 2018 Dec 20; Linzey, et al
Disparities in Inter-Hospital Helicopter Transport, J Stroke Cerebrovasc Dis; ePub 2018 Dec 11; Sarrazin, et al
Mild-to-Moderate OSA Linked with Hypertension, Sleep; ePub 2018 Dec 22; Vgontzas, et al
Aspirin Reduces Stroke Risk in Women with Prior HDP, Neurology; ePub 2018 Dec 26; Miller, Boehme, et al
Must Reads in Alzheimer's & Cognition
Female Veterans, Military-Related Risk, and Dementia, Neurology; ePub 2018 Dec 12; Yaffe, et al
Retinal Signs and Risk of Incident Dementia, Alzheimers Dement; ePub 2018 Nov 12; Deal, et al
Impact of Amyloid-Beta, Tau on Cognitive Decline, Ann Neurol; ePub 2018 Dec 14; Sperling, et al
Vegetable/Fruit Intake Benefits Cognitive Function, Neurology; ePub 2018 Nov 21; Yuan, Fondell, et al
Alzheimer Dementia and Age-Related Neuropathologies, Ann Neurol; ePub 2018 Nov 12; Boyle, Yu, et al