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Glucose Levels and Dementia in African Americans

Alzheimers Dement; ePub 2018 Apr 17; Hendrie, et al

Significant changes in glucose levels precede dementia in African-American patients with diabetes but not in Caucasians, a recent study found. A secondary data analysis using electronic medical records from 5,228 African-Americans and Caucasians aged ≥65 years was carried out. Mixed effects models with repeated serum glucose measurements were used to compare changes in glucose levels between African-Americans and Caucasian patients with and without incident dementia. Researchers found:

  • African-Americans and Caucasians with diabetes had significantly different changes in glucose levels by dementia status.
  • African-Americans experienced a significant decline in glucose levels before the dementia diagnosis (estimated glucose decline 1.3421 mg/dL per year) than those who did not develop dementia.
  • Caucasians with and without dementia showed stable glucose levels over time.

Hendrie HC, Zheng M, Lane KA, et al. Changes of glucose levels precede dementia in African-Americans with diabetes but not in Caucasians. [Published online ahead of print April 17, 2018]. Alzheimers Dement. doi:10.1016/j.jalz.2018.03.008.