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Genetic Basis of Motoric Cognitive Risk Syndrome

Neurology; ePub 2019 Feb 8; Sathyan, et al

Obesity-related genetic traits increase risk of motoric cognitive risk syndrome (MCR), a pre-dementia syndrome characterized by the presence of subjective cognitive complaints and slow gait, according to a recent study. Researchers analyzed 4,915 individuals, aged ≥65 years, with European ancestry (mean age 75.0 ± 6.8 years, 56.6% women) in the Health and Retirement Study. They found:

  • There were 260 prevalent MCR cases, 529 with slow gait, and 1,928 with subjective cognitive complaints.
  • Higher PGSs for BMI (OR 1.22) and waist circumference (OR 1.23) were associated with MCR, and PGS of AD showed a suggestive association (OR 1.16).
  • Higher PGS for neuroticism (OR 1.10) was associated with cognitive complaints, whereas higher well-being PGS (OR 0.92) was protective.
  • PGS for BMI (OR 1.16), waist circumference (OR 1.19), and AD (OR 1.13) was associated with slow gait.

Sathyan S, Wang T, Ayers E, Verghese J. Genetic basis of motoric cognitive risk syndrome in the Health and Retirement Study. [Published online ahead of print February 8, 2019]. Neurology. 10.1212/WNL.0000000000007141.