Key clinical point: The level of neurofilament light in CSF reflects neuroaxonal damage.
Major finding: Mean CSF NfL was significantly higher in frontotemporal dementia, compared with Alzheimer’s disease (2.08), vascular dementia (1.56), and dementia with Lewy bodies (2.50).
Study details: A systematic review and meta-analysis of data for 10,059 patients with neurologic disorders.
Disclosures: The authors received funding from various companies and foundations that did not influence the study.
Bridel C et al. JAMA Neurol. 2019 June 17. doi: 10.1001/jamaneurol.2019.1534.