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CSF Neurofilament Light Level Could Aid in Diagnosis

Key clinical point: The level of neurofilament light in CSF reflects neuroaxonal damage.

Major finding: Mean CSF NfL was significantly higher in frontotemporal dementia, compared with Alzheimer’s disease (2.08), vascular dementia (1.56), and dementia with Lewy bodies (2.50).

Study details: A systematic review and meta-analysis of data for 10,059 patients with neurologic disorders.

Disclosures: The authors received funding from various companies and foundations that did not influence the study.


Bridel C et al. JAMA Neurol. 2019 June 17. doi: 10.1001/jamaneurol.2019.1534.