Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Cardiovascular disease is implicated in link between air pollution and dementia

Key clinical point: Most of the association of air pollution with dementia appears to occur through the presence or development of cardiovascular disease.

Major finding: The elevation of dementia risk related to particulate matter ≤2.5 μm exposure was greater among older adults who had heart failure (HR, 1.93) or ischemic heart disease (HR, 1.67); preceding stroke explained 49% of dementia cases related to such exposure.

Study details: A Swedish longitudinal, population-based cohort study of 2,927 initially dementia-free older adults aged 60 years or older in the Swedish National Study on Aging and Care in Kungsholmen (SNAC-K) study.

Disclosures: Dr. Grande disclosed no relevant conflicts of interest. The study was funded by the Swedish National Study on Aging and Care in Kungsholmen (SNAC-K); the Swedish Ministry of Health and Social Affairs; the participating County Councils and Municipalities; the Swedish Research Council; funding for doctoral education from the Karolinska Institutet; and the Swedish Research Council for Health, Working Life and Welfare.

Citation:

Grande G et al. JAMA Neurol. 2020. doi:10.1001/jamaneurol.2019.4914.