Clinical Edge

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Atherosclerosis Increases Risk of Post-Stroke Dementia

Atherosclerosis may be associated with an increased risk of post-stroke dementia, a new study found. The systematic review and meta-analysis included randomized controlled trials or observational cohort studies conducted among patients with stroke and reported on the association of blood lipids, atherosclerosis or statin use with dementia or cognitive impairment. Study details included:

  • 56 studies comprising 38,423 stroke patients.
  • Peripheral artery disease was associated with dementia and cognitive impairment.
  • For coronary heart disease, the pooled odds ratio (OR) of dementia and cognitive impairment was 1.32 and 1.23, respectively.
  • Post-stroke statin use was associated with decreased risk of cognitive impairment.
  • No associated was observed for hypercholesterolemia.


Yang Z, et al. Association of blood lipids, atherosclerosis and statin use with dementia and cognitive impairment after stroke: a systematic review and meta-analysis. Ageing Res Rev. doi: 10.1016/j.arr.2019.100962.