Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Anticholinergic Drugs Linked to Dementia in Older Populations

Key clinical point: A large pharmacoepidemiologic study found an association between anticholinergic drug exposure and dementia risk in people aged 55 years or older.

Major finding: Exposure to various types of anticholinergic medications were associated with a significantly increased risk of dementia.

Study details: A nested case-control study of 58,769 patients with dementia and 225,574 matched controls.

Disclosures: The study was supported by the National Institute for Health Research and the University of Nottingham. The authors reported financial affiliations with ClinRisk Ltd.


Coupland C et al. JAMA Intern Med. 2019 Jun 24. doi: 10.1001/jamainternmed.2019.0677