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Alzheimer’s Disease Subtypes Follow Neuropathologic Patterns Seen in The Nucleus Basalis of Meynert

Key clinical point: Patterns of neurofibrillary tangles in the nucleus basalis of Meynert (nbM) vary with Alzheimer’s disease (AD) subtype.

Major finding: The number of neurofibrillary tangles in the nbM was highest in hippocampal-sparing AD and lowest in limbic predominant AD.

Study details: The retrospective autopsy study comprised 1,361 samples from confirmed AD cases.

Disclosures: This study was supported by the National Institute on Aging, the Florida Department of Health, the Ed and Ethel Moore Alzheimer’s Disease Research Program, a Gerstner Family Career Development Award, and the Alzheimer’s Association. Two authors reported financial relationships with industry outside the submitted work.


Al-Shaikh FSH et al. JAMA Neurol. 2019 Oct 28. doi: 10.1001/jamaneurol.2019.3606.