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PD-L1-Positive NSCLC and KEYNOTE-024, by Bobby Daly, MD, MBA
Question 1 of 5

You are evaluating a 70-year-old new patient in your lung cancer clinic with stage IV non–small-cell lung cancer with metastases to the liver and bone. The patient’s brain MRI is negative for metastases. The histologic subtype of the lung cancer is squamous. The patient’s medical history is notable for rheumatoid arthritis but he has not received systemic treatment for 3 years. On exam, the patient’s Eastern Cooperative Oncology Group performance status is a 2. You recently read the KEYNOTE-024 trial, pembrolizumab versus the investigator’s choice of cytotoxic chemotherapy as a first-line therapy for patients with advanced non–small-cell lung cancer. Your patient would not have met the inclusion criteria for this study for which of the following reasons?

The study did not include patients with squamous histology

The study did not include patients with a history of autoimmune disease

The study only included patients with an Eastern Cooperative Oncology Group performance status of 0 or 1

The study did not include patients older than 65 years-old

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