Acute Myeloid Leukemia
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Pankit Vachhani, MD

Clinical Fellow, Roswell Park Comprehensive Cancer Center, Buffalo, NY

Elizabeth A. Griffiths, MD

Associate Professor of Oncology, Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY

Read the full article Acute Myeloid Leukemia.

Question 1 of 5

A 79-year-old woman with a history of hypertension, heart failure with ejection fraction of 45%, and rheumatoid arthritis managed with methotrexate is diagnosed with adverse-risk cytogenetics acute myeloid leukemia (AML). Laboratory findings are notable for a white blood cell (WBC) count of 2000/µL with 25% blasts, hemoglobin 8.0 g/dL, platelet count 76 × 103/µL, serum creatinine 0.8 mg/dL, alanine aminotransferase (ALT) 20 U/L, and aspartate aminotransferase (AST) 22 IU/L. Despite some fatigue and dyspnea on exertion, she is ambulatory and able to take care of her household chores.

What is the most reasonable next management course to recommend?

Intensive chemotherapy with anthracycline and cytarabine

Intensive chemotherapy with CPX-351 (liposomal 5:1 molar concentration of cytarabine and daunorubicin)

Hypomethylating agent

Basic supportive care (predominantly transfusions)

Hospice referral

Hospital Physician: Hematology/Oncology. 2018 August;13(4)

This quiz is not accredited for CME.

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