Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

This Week's Must Reads

Higher AML, MDS risk linked to autotransplants, Radivoyevitch T et al. Leuk Res. 2018 Jul 19. pii: S0145-2126(18)30160-7

CMS wants to flatten E/M payments, CMS proposed rule, CMS-1693-P

Lay health workers can assist with end-of-life care, Patel MI et al. JAMA Oncology. 2018 Jul 26. doi: 10.1001/jamaoncol.2018.2446.

New guidelines from the UK on chronic lymphocytic leukemia, Schuh AH et al. Br J Haematol. 2018 Jul 15. doi: 10.1111/bjh.15460

JAK1/2 inhibitors tied to increased B-cell lymphoma risk, Porpaczy E et al. Blood. 2018 Jun 14. doi: 10.1182/blood-2017-10-810739.

Patient & Survivor Care

Lay health workers can assist with end-of-life care, Patel MI et al. JAMA Oncology. 2018 Jul 26. doi: 10.1001/jamaoncol.2018.2446.

Second filgrastim biosimilar approved by FDA, U.S. FDA Approves Pfizer’s Biosimilar NIVESTYM™ (filgrastim-aafi), Pfizer press release

Read more in Patient & Survivor Care

Breast Cancer

Statins and Survival in Patients with Cancer, JAMA Oncol; ePub 2017 Aug 22; Emilsson, et al

FDA Approves Faslodex for Certain Breast Cancers, AstraZeneca news release; 2017 Aug 28

Read more in Breast Cancer

CNS/Brain Cancer

FDA Approves First Biosimilar to Treat Cancer, FDA news release; 2017 Sep 14

Chemo Regimens for High-Grade Gliomas, Cochrane; 2017 Jul 26; Parasramka, Talari, et al

Read more in CNS/Brain Cancer

Leukemia, Myelodysplasia, Transplantation

New Choosing Wisely Guidance on BMT Released , Biol Blood Marrow Transplant; ePub 2018 Jan 19; Bhella, et al

Second Primary Malignancies in Patients with MM, Biol Blood Marrow Transplant; ePub 2018 Jan 12; Sahebi, et al

Read more in Leukemia, Myelodysplasia, Transplantation

Thrombosis

Poor adherence to DOAC therapy requires attention, Lakkireddy D et al. Heart Rhythm 2018, Abstract B-LBCT02-03.

Sepsis-related coagulopathy and in-hospital death risk, Lyons PG et al. Crit Care Med. 2018 May;46(5):73642.

Read more in Thrombosis

Bleeding Disorders

Avatrombopag reduces procedure-related transfusions in chronic liver disease and thrombocytopenia, Terrault N et al. Gastroenterology. 2018 May 17. doi: 10.1053/j.gastro.2018.05.025.

Prehospital plasma improves odds of survival in hemorrhagic shock, Sperry JL et al. N Engl J Med. 2018 Jul 26;379(4):315-26.

Read more in Bleeding Disorders

Transfusion Medicine

Diarrhea more severe in those with Type A blood, Kumar P et al. J Clin Invest. 2018 May 17; doi: 10.1172/JCI97659.

Transfusions cut by cell salvage in abdominal myomectomy, Gingold J et al. SGS 2018 Oral poster 18.

Read more in Transfusion Medicine

Anemia

Fewer sickle cell crises with L-glutamine use, Niihara Y et al. N Engl J Med. 2018 Jul 19;379(3):226-35.

Hydroxyurea tolerated well in sickle cell patients, Dauvergne B et al. FSCDR 2018 (annual meeting of the Foundation for Sickle Cell Disease Research), presentation JSCDH-D-18-00052.

Read more in Anemia

Genitourinary Cancer

Cochrane on EDMA for Bladder Cancer Treatment, Cochrane; 2017 Sep 12; Jung, Gudeloglu, et al

Cochrane on Surgical Approaches for Prostatectomy , Cochrane; 2017 Sep 12; Ilic, Evans, Allan, et al

Read more in Genitourinary Cancer