Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

This Week's Must Reads

Oncologists file suit challenging Part B payment reductions, May 30 letter to HHS Secretary Alex Azar alerting him to the legal action, which was filed on May 31.

One-third of IDH1-mutated AML cases have complete response to ivosidenib , Pollyea DA, et al. J Clin Oncol 36, 2018 (suppl) annual meeting of the American Society of Clinical Oncology; abstr 7000.

Ruxolitinib add-on boosted myeloma response, Berenson JR, et al. J Clin Oncol 36, 2018, suppl. (ASCO 2018, annual meeting of the American Society of Clinical Oncology); abstr 8005.

Getting to MRD in ALL boosted survival, Hay KA. ASCO 2018 (annual meeting of the American Society of Clinical Oncology), Abstract 7005.

CLL gets to MRD with combo therapy, Wierda WG et al. ASCO 2018 (annual meeting of the American Society of Clinical Oncology), Abstract 7502.

Patient & Survivor Care

Skin side effects of therapies for hematologic cancers, Phillips et al. J Am Acad Dermatol. 2018;78:1102-9.

Monetary support affects select prescribing, Mitchell AP et al. JAMA Intern Med. 2018 Apr 9. doi: 0.1001/jamainternmed.2018.0776

Read more in Patient & Survivor Care

Breast Cancer

Statins and Survival in Patients with Cancer, JAMA Oncol; ePub 2017 Aug 22; Emilsson, et al

FDA Approves Faslodex for Certain Breast Cancers, AstraZeneca news release; 2017 Aug 28

Read more in Breast Cancer

CNS/Brain Cancer

FDA Approves First Biosimilar to Treat Cancer, FDA news release; 2017 Sep 14

Chemo Regimens for High-Grade Gliomas, Cochrane; 2017 Jul 26; Parasramka, Talari, et al

Read more in CNS/Brain Cancer

Leukemia, Myelodysplasia, Transplantation

New Choosing Wisely Guidance on BMT Released , Biol Blood Marrow Transplant; ePub 2018 Jan 19; Bhella, et al

Second Primary Malignancies in Patients with MM, Biol Blood Marrow Transplant; ePub 2018 Jan 12; Sahebi, et al

Read more in Leukemia, Myelodysplasia, Transplantation

Thrombosis

Sepsis-related coagulopathy and in-hospital death risk, Lyons PG et al. Crit Care Med. 2018 May;46(5):73642.

New cancer drugs linked to fewer arrhythmias, Nickel A et al. annual meeting of the American College of Cardiology ACC 18, Abstract #900-06.

Read more in Thrombosis

Bleeding Disorders

Dapagliflozin suppresses hepcidin, boosts hematocrit, Ghanim HA et al. AACE 2018, Abstract 228.

In hemophilia A, reduced frequency prophylaxis was safe, cut costs, Feldman BM et al. Lancet Haematol. 2018 May 3. doi: 10.1016/S2352-3026(18)30048-6.

Read more in Bleeding Disorders

Transfusion Medicine

Diarrhea more severe in those with Type A blood, Kumar P et al. J Clin Invest. 2018 May 17; doi: 10.1172/JCI97659.

Transfusions cut by cell salvage in abdominal myomectomy, Gingold J et al. SGS 2018 Oral poster 18.

Read more in Transfusion Medicine

Genitourinary Cancer

Cochrane on EDMA for Bladder Cancer Treatment, Cochrane; 2017 Sep 12; Jung, Gudeloglu, et al

Cochrane on Surgical Approaches for Prostatectomy , Cochrane; 2017 Sep 12; Ilic, Evans, Allan, et al

Read more in Genitourinary Cancer