Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Lymph Node Removal During Endometrial Ca Surgery

Cochrane; 2017 Oct 2; Frost, Webster, et al

Lymphadenectomy does not appear to decrease either mortality risk or disease recurrence in women with presumed stage I endometrial cancer, according to a Cochrane review of 2 trials involving nearly 2,000 women. The procedure was found to be linked with more severe adverse events. Among the specific findings:

  • There is no evidence that women who received lymphadenectomy were less likely to die or have a relapse of their cancer (based on moderate quality evidence).
  • Lymphadenectomy resulted in surgery-related morbidity and lymphoedema/lymphocyst formation (based on high quality evidence).

Citation:

Frost J, Webster K, Bryant A, Morrison J. Lymphadenectomy for the management of endometrial cancer. Cochrane Database of Syst Rev. 2017, Issue 10. Art. No.: CD007585. doi:10.1002/14651858.CD007585.pub4.

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CD8+ Tumor-Infiltrating Lymphocytes and Ovarian Ca, JAMA Oncol; ePub 2017 Oct 12; OTTA Consortium

Lymph Node Removal During Endometrial Ca Surgery, Cochrane; 2017 Oct 2; Frost, Webster, et al

Cochrane on Reducing Neoplasia in Molar Pregnancy, Cochrane; 2017 Sep 11; Wang, Fu, Hu, et al

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