Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Cochrane On Bisphosphonates for Prostate Cancer

Cochrane; 2017 Dec 26; Macherey, Monsef, et al

Men with bone metastases from prostate who took bisphosphonates or control regimens experienced similar responses to pain, according to a Cochrane review of 18 clinical trials. The reviews found that bisphosphonates:

  • Provided no clinically relevant difference in pain response vs placebo or no additional treatment, based on low quality evidence.
  • Reduced pain in 40 more men/1,000.
  • Appear to result in 58 fewer skeletal-related events/1,000.
  • Showed no clear difference in the number of men who died or took fewer pain killers.
  • Probably increased the number of men with nausea, based on moderate quality evidence.
  • Probably increased the number of men with kidney problems, based on moderate quality evidence.
  • Showed no clear difference in patients who experienced osteonecrosis of the jaw, based on very low quality evidence.
  • Probably decreased the number of men affected by disease progression, according to moderate quality evidence.

Citation:

Macherey S, Monsef I, Jahn F, et al. Bisphosphonates for advanced prostate cancer. Cochrane Database of Syst Rev. 2017, Issue 12. Art. No.: CD006250. doi:10.1002/14651858.CD006250.pub2.

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ASCO Guideline on Alcohol Consumption and Cancer, J Clin Oncol; 2018 Jan; LoConte, Brewster, et al

Cochrane On Bisphosphonates for Prostate Cancer, Cochrane; 2017 Dec 26; Macherey, Monsef, et al

Cochrane on Vaccine-Based Immunotherapy for NSCLC, Cochrane; 2017 Dec 16; Zhu, Li, Tiselius, et al

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Cochrane On Bisphosphonates for Prostate Cancer, Cochrane; 2017 Dec 26; Macherey, Monsef, et al

Cochrane on Reconstructing the Pancreatic Stump, Cochrane; 2017 Sep 12; Cheng, Briarava, et al

Cochrane on EDMA for Bladder Cancer Treatment, Cochrane; 2017 Sep 12; Jung, Gudeloglu, et al

Cochrane on Surgical Approaches for Prostatectomy , Cochrane; 2017 Sep 12; Ilic, Evans, Allan, et al

FDA Approves First Biosimilar to Treat Cancer, FDA news release; 2017 Sep 14