Stereotactic radiosurgery (SRS) plus whole brain radiation therapy (WBRT) improves survival in certain patients with brain metastases, according to a Cochrane review of 3 trials. Among the findings, based on moderate quality evidence:
- Overall, participants who underwent WBRT and SRS did not survive longer than participants who were treated with WBRT alone.
- Patients who were able to perform activities of daily life in a highly functional way, as well as those with a single metastasis, survived longer after combination therapy.
- Those given combined treatment experienced better local control and performance status, and used steroids less frequently.
Patil C, Pricola K, Sarmiento J, Garg S, Bryant A, Black K. Whole brain radiation therapy (WBRT) alone versus WBRT and radiosurgery for the treatment of brain metastases. Cochrane Database of Syst Rev. 2017, Issue 9. Art. No.: CD006121. doi:10.1002/14651858.CD006121.pub4.
This Week's Must Reads
ASCO Guideline on Alcohol Consumption and Cancer, J Clin Oncol; 2018 Jan; LoConte, Brewster, et al
Cochrane On Bisphosphonates for Prostate Cancer, Cochrane; 2017 Dec 26; Macherey, Monsef, et al
Cochrane on Vaccine-Based Immunotherapy for NSCLC, Cochrane; 2017 Dec 16; Zhu, Li, Tiselius, et al
Stereotactic Radiotherapy System Approved For BC, FDA news release; 2017 Dec 22
Perjeta Approved for Certain Type of Early BC, Genentech news release; 2017 Dec 20
Must Reads in CNS/Brain Cancer
Cochrane on Radiosurgery, Radiation for Brain Ca, Cochrane; 2017 Sep 25; Patil, Pricola, et al
FDA Approves First Biosimilar to Treat Cancer, FDA news release; 2017 Sep 14
Chemo Regimens for High-Grade Gliomas, Cochrane; 2017 Jul 26; Parasramka, Talari, et al
FDA Approves Gleolan for Use During Glioma Surgery, IDT Biologika news release; 2017 Jun 6
Cochrane on Sampling or Removal of Low-Grade Glioma, Cochrane; 2017 Apr 27; Jiang, Chaichana, et al