To effectively address the many emerging viral diseases worldwide, vaccine developers need to think outside the box and embrace many of the modern-day technologies now available, according to Barney Graham, MD, John Mascola, MD, and Anthony Fauci, MD.
- The experts point out that development of vaccines typically takes 15 to 20 years from the time a virus is discovered to the time a vaccine is available.
- That long wait can be substantially shortened in many cases if developers took advantage of a variety of second-generation tools.
- Among the latest technologies worth considering: synthetic vaccinology, which uses viral gene sequence data to speed up the vaccine development process.
- This sequencing data can be used to manufacture nucleic acids that encode the viral surface proteins, for instance.
- Using this approach, it is possible for DNA plasmids to encode viral proteins for preclinical testing within a few weeks.
Graham BS, Mascola JR, Fauci AS. Novel vaccine technologies essential components of an adequate response to emerging viral diseases. JAMA. 2018;319:1431-1432. doi:10.1001/jama.2018.0345.
This Week's Must Reads
AHA Statement: Accurate Measurement of BP, Hypertension; ePub 2019 Mar 4; Muntner, et al
Coffee Consumption & Plasma Biomarkers, Am J Clin Nutr; ePub 2019 Mar 5; Hang, et al
Is Adding Aspirin to Warfarin Therapy Beneficial? , JAMA Intern Med; ePub 2019 Mar 4; Schaefer, et al
Urinary Oxalate Excretion & Risk of CKD Progression, JAMA Intern Med; ePub 2019 Mar 4; Waikar, et al
Psychosocial Stress & CV Health in Older Women, Circulation; ePub 2019 Feb 28; Burroughs-Peña, et al
Must Reads in Vaccines
Vaccination for Prevention of Herpes Zoster, Ann Intern Med; ePub 2019 Feb 19; Prosser, et al
ACIP Updates Adult Immunization Schedule, Ann Intern Med; 2019 Feb 5; Kim, Hunter, et al
Influenza Vaccination Safety During Hospitalization, Mayo Clin Proc; ePub 2019 Jan 8; Tartof, et al
AAP Revision on Dismissing Vaccine-Refusing Families, JAMA Pediatr; ePub 2018 Apr 30; Deem, et al