Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Ineffective Pneumococcal Vaccine in Children

Open Forum Infect Dis; ePub 2018 Feb 17; Martin, et al

Although initial changes in Haemophilus influenzae colonization of children’s nasopharynxes may have suggested that pneumococcal conjugate vaccines (PCVs) are having an impact among children with acute otitis media, over time those increases have not been sustained, according to 4 separate studies.

  • Among children in cohort 1, who were recruited before routine use of PCV7, colonization with vaccine serotypes of H. influenzae was 26%.
  • In cohort 2, 93% of whom received ≥2 doses of the vaccine, and cohort 3, all of whom received it, colonization reached 41% and 33% respectively.
  • But cohort 4, all of whom received ≥2 or more doses of PCV13, colonization had dropped to 29%.


Martin JM, Hoberman A, Shaikh N, et al. Changes over time in nasopharyngeal colonization in children under 2 years of age at the time of diagnosis of acute otitis media (1999–2014). [Published online ahead of print February 17, 2018]. Open Forum Infect Dis. doi:10.1093/ofid/ofy036.

This Week's Must Reads

Do Vitamin D Supplements Prevent Cancer, CVD?, N Engl J Med; 2019 Jan 3; Manson, Cook, et al

Nonadherence to Cancer Screenings & Related Mortality, JAMA Intern Med; ePub 2018 Dec 28; Pierre-Victor, et al

Alcohol Consumption After Development of HF, JAMA Netw Open; ePub 2018 Dec 28; Sadhu, et al

Opioid-Involved Overdose Deaths in the US, MMWR; 2019 Jan 4; Scholl, Seth, et al

Assessing the Diet Quality of US Children, Am J Clin Nutrit; ePub 2018 Dec 29; Thomson, et al

Must Reads in Vaccines

AAP Revision on Dismissing Vaccine-Refusing Families, JAMA Pediatr; ePub 2018 Apr 30; Deem, et al

Creating Preventive Vaccines for Lynch Syndrome, JAMA Oncology; ePub 2018 Apr 16; Chang, et al

Children with Autism Less Likely to Be Vaccinated, JAMA Pediatr; ePub 2018 Mar 26; Zerbo, et al

Antibody-Based Vaccines & Intracellular Pathogens, Curr Opin Immunol; ePub 2018 Apr 25; Casadevall

Designing an Effective Hepatitis C Vaccine, Trends Microbiol; ePub 2018 Apr 24; Kinchen, et al