Because HIV-infected adults are at risk of developing anal and oropharyngeal cancer, a phase 3 randomized trial was done to test the effectiveness of a vaccine against human papillomavirus infection. The vaccine proved ineffective in preventing new anal HPV infections or improving clinical outcomes among patients with high-grade squamous intraepithelial lesions (HSIL).
- The phase 3 placebo controlled double-blind study randomized 575 adults aged ≥27 years.
- The quadrivalent HPV vaccine was only efficacious in 22% of patients for preventing persistent anal infection.
- Efficacy was 0% for its ability to improve HSIL outcomes.
- The efficacy of the vaccine was 88% for preventing persistent oral HPV infection but only 32% efficacious for 6-month persistent oral HPV infection or detection at the final visit.
Wilkin TJ, Chen H, Cespedes MS, et al. A randomized, placebo-controlled trial of the quadrivalent HPV vaccine in HIV-infected adults age 27 years or older: AIDS clinical trials group protocol A5298. [Published online ahead of print April 5, 2018]. Clin Infect Dis. doi:10.1093/cid/ciy274.
This Week's Must Reads
Is Obesity Associated With Adverse CV Outcomes?, JAMA Netw Open; 2018 Nov 16; Riaz, et al
BMI & Risk of Postpregnancy T2D in Women with HDP , Diabetes Care; ePub 2018 Nov 19; Timpka, et al
Diabetes Outcomes in Patients by PCPs, NPs, or PAs, Ann Intern Med; ePub 2018 Nov 20; Jackson, et al
Traumatic Exposures & Health Issues in Older Women, JAMA Intern Med; ePub 2018 Nov 19; Gibson, et al
Risk of Opioid Overdose Hospitalizations , J Am Board Fam Med; 2018 Nov-Dec; Peters, et al
Must Reads in Vaccines
AAP Revision on Dismissing Vaccine-Refusing Families, JAMA Pediatr; ePub 2018 Apr 30; Deem, et al
Creating Preventive Vaccines for Lynch Syndrome, JAMA Oncology; ePub 2018 Apr 16; Chang, et al
Children with Autism Less Likely to Be Vaccinated, JAMA Pediatr; ePub 2018 Mar 26; Zerbo, et al
Antibody-Based Vaccines & Intracellular Pathogens, Curr Opin Immunol; ePub 2018 Apr 25; Casadevall
Designing an Effective Hepatitis C Vaccine, Trends Microbiol; ePub 2018 Apr 24; Kinchen, et al