Because HIV-infected adults are at risk of developing anal and oropharyngeal cancer, a phase 3 randomized trial was done to test the effectiveness of a vaccine against human papillomavirus infection. The vaccine proved ineffective in preventing new anal HPV infections or improving clinical outcomes among patients with high-grade squamous intraepithelial lesions (HSIL).
- The phase 3 placebo controlled double-blind study randomized 575 adults aged ≥27 years.
- The quadrivalent HPV vaccine was only efficacious in 22% of patients for preventing persistent anal infection.
- Efficacy was 0% for its ability to improve HSIL outcomes.
- The efficacy of the vaccine was 88% for preventing persistent oral HPV infection but only 32% efficacious for 6-month persistent oral HPV infection or detection at the final visit.
Wilkin TJ, Chen H, Cespedes MS, et al. A randomized, placebo-controlled trial of the quadrivalent HPV vaccine in HIV-infected adults age 27 years or older: AIDS clinical trials group protocol A5298. [Published online ahead of print April 5, 2018]. Clin Infect Dis. doi:10.1093/cid/ciy274.
This Week's Must Reads
Screening for Syphilis Infection in Pregnant Women, JAMA; 2018 Sep 4; US Preventive Services Task Force
Treatment Intensification Guidelines for T2D , Ann Intern Med; ePub 2018 Sep 4; Roglic, et al
Immediate vs Gradual Nicotine Reduction in Cigarettes, JAMA; ePub 2018 Sep 4; Hatsukami, et al
Prevalence of Diabetes Among US Adults, BMJ; ePub 2018 Aug 27; Xu, Liu, et al
Effect of Fish Oil Supplementation in Pregnancy, BMJ; ePub 2018 Sep 4; Vinding, Stokholm, et al
Must Reads in Vaccines
AAP Revision on Dismissing Vaccine-Refusing Families, JAMA Pediatr; ePub 2018 Apr 30; Deem, et al
Creating Preventive Vaccines for Lynch Syndrome, JAMA Oncology; ePub 2018 Apr 16; Chang, et al
Children with Autism Less Likely to Be Vaccinated, JAMA Pediatr; ePub 2018 Mar 26; Zerbo, et al
Antibody-Based Vaccines & Intracellular Pathogens, Curr Opin Immunol; ePub 2018 Apr 25; Casadevall
Designing an Effective Hepatitis C Vaccine, Trends Microbiol; ePub 2018 Apr 24; Kinchen, et al