Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

HPV Vaccine Proves Ineffective in HIV Patients

Clin Infect Dis; ePub 2018 Apr 5; Wilkin, et al

Because HIV-infected adults are at risk of developing anal and oropharyngeal cancer, a phase 3 randomized trial was done to test the effectiveness of a vaccine against human papillomavirus infection. The vaccine proved ineffective in preventing new anal HPV infections or improving clinical outcomes among patients with high-grade squamous intraepithelial lesions (HSIL).

  • The phase 3 placebo controlled double-blind study randomized 575 adults aged ≥27 years.
  • The quadrivalent HPV vaccine was only efficacious in 22% of patients for preventing persistent anal infection.
  • Efficacy was 0% for its ability to improve HSIL outcomes.
  • The efficacy of the vaccine was 88% for preventing persistent oral HPV infection but only 32% efficacious for 6-month persistent oral HPV infection or detection at the final visit.


Wilkin TJ, Chen H, Cespedes MS, et al. A randomized, placebo-controlled trial of the quadrivalent HPV vaccine in HIV-infected adults age 27 years or older: AIDS clinical trials group protocol A5298. [Published online ahead of print April 5, 2018]. Clin Infect Dis. doi:10.1093/cid/ciy274.

This Week's Must Reads

Global Burden of CVD in People Living with HIV, Circulation; ePub 2018 Jul 2; Shah, et al

Penicillin Allergy & Risk of MRSA and C. difficle, BMJ; ePub 2018 Jun 27; Blumenthal, et al

Does Sleep Debt Decrease with Age? , Sleep Health; ePub 2018 Jun 28; Fox, et al

Firearm Injuries in Children & Adolescents, Pediatrics; ePub 2018 Jul 2; Herrin, et al

Effects of Pulse Pressure & BP Tx Intensity on AEs, Am J Med; ePub 2018 Jun 22; Krishnaswami, et al

Must Reads in Vaccines

Does Chronic Kidney Disease Affect Vaccine Response?, PLoS One; 2018 Apr 16; Wall, et al

Zoster and Pneumococcal Vaccines Are Compatible , Am J Epidemiol; ePub 2018 Apr 11; Bruxvoort, et al

HPV Vaccine Proves Ineffective in HIV Patients, Clin Infect Dis; ePub 2018 Apr 5; Wilkin, et al

Age Matters During a Pertussis Outbreak, Open Forum Infect Dis; 2018 Apr 16; Goldstein, et al

Newer Vaccine Technologies Can Speed Response, JAMA; 2018 Apr 10; Graham, Mascola, et al