Administering a typhoid Vi conjugate vaccine to residents in poor countries would be cost-effective in settings in which the incidence of the infection is 50 cases/100,000 annually, based on a computer model that takes into account various vaccination strategies.
- Investigators reached that conclusion by creating a dynamic, age-structured transmission model that mimicked several vaccination strategies.
- The model simulated 10-year programs that involved routine immunization of infants younger than age 1 year using the Expanded Program on Immunization (EPI), and adding a 1-time catch-up program for children aged 5 to 14 years.
- The immunization model that used EPI and more than 50 cases/100,000 was highly cost effective. Adding the catch-up component was cost effective when the annual incidence was >130 cases/100,000.
Lo NC, Gupta R, Stanaway JD, et al. Comparison of strategies and incidence thresholds for Vi conjugate vaccines against typhoid fever: A cost-effectiveness modeling study. [Published online ahead of print February 12, 2018]. J Infect Dis. doi:10.1093/infdis/jix598.
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Designing an Effective Hepatitis C Vaccine, Trends Microbiol; ePub 2018 Apr 24; Kinchen, et al