Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Developing Cost Effective Typhoid Fever Vaccines

J Infect Dis; ePub 2018 Feb 12; Lo, Gupta, et al

Administering a typhoid Vi conjugate vaccine to residents in poor countries would be cost-effective in settings in which the incidence of the infection is 50 cases/100,000 annually, based on a computer model that takes into account various vaccination strategies.

  • Investigators reached that conclusion by creating a dynamic, age-structured transmission model that mimicked several vaccination strategies.
  • The model simulated 10-year programs that involved routine immunization of infants younger than age 1 year using the Expanded Program on Immunization (EPI), and adding a 1-time catch-up program for children aged 5 to 14 years.
  • The immunization model that used EPI and more than 50 cases/100,000 was highly cost effective. Adding the catch-up component was cost effective when the annual incidence was >130 cases/100,000.

Lo NC, Gupta R, Stanaway JD, et al. Comparison of strategies and incidence thresholds for Vi conjugate vaccines against typhoid fever: A cost-effectiveness modeling study. [Published online ahead of print February 12, 2018]. J Infect Dis. doi:10.1093/infdis/jix598.

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