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RA-related Autoantibodies and Pulmonary Function Test Abnormalities

Seropostive patients with rheumatoid arthritis (RA) had 2-fold risk for abnormalities on pulmonary function test (PFT) performed for clinical indications compared with seronegative PA, a new study found. Researchers studied RA serostatus and PFT abnormalities within a RA registry. They found:

  • Among 1,272 analyzed participants, mean age was 56.3 years, 82.2% were female, and 69.5% were seropositive.
  • Compared with seronegativity, seropositivity was associated with increased odds of any PFT abnormality.
  • Higher titers of rheumatoid factor conferred greatest risk for all PFT outcomes: obstruction, restriction, and diffusion abnormality.


Huang S, et al. Association of rheumatoid arthritis-related autoantibodies with pulmonary function test abnormalities in a rheumatoid arthritis registry. [Published online ahead of print August 13, 2019]. Clin Rheumatol. doi: 10.1007/s10067-019-04733-9.