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Family Disease History Found Pertinent to RA Risk

Key clinical point: Risk of rheumatoid arthritis (RA) was significantly increased for individuals with a family history of conditions including rheumatologic autoimmune diseases, pulmonary fibrosis, inflammatory bowel disease, hyper- and hypothyroidism, and obstructive sleep apnea.

Major finding: The adjusted odds ratios for rheumatoid arthritis were 1.89 with a family history of rheumatologic autoimmune diseases, 2.12 with pulmonary fibrosis, 1.45 with inflammatory bowel disease, 1.34 with hyper- or hypothyroidism, and 1.28 with obstructive sleep apnea. Parkinson’s disease and type 2 diabetes were associated with a decreased risk that did not reach the level of statistical significance specified in the study.

Study details: The data come from a case-control study of 821 patients with rheumatoid arthritis from the Mayo Clinic databank and three matched controls for each.

Disclosures: The researchers were supported in part by grants from the Rheumatology Research Foundation and the National Institute for Arthritis and Musculoskeletal and Skin Diseases. They had no financial conflicts to disclose.


Kronzer VL et al. Arthritis Care Res. 2019 Nov 30. doi: 10.1002/ACR.24115