Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Psoriasis may raise risk of aortic aneurysm

Key clinical point: Consider screening for aortic aneurysm in psoriasis patients.

Major finding: Psoriasis patients showed a significantly increased risk of developing aortic aneurysm compared with controls (hazard ratio 1.30) and the risk was not significantly different based on psoriasis severity, age, gender, or the presence of diabetes.

Study details: The data come from a systematic review of 3 large cohort studies including 5,706,525 individuals; 24,864 were psoriasis cases.

Disclosures: The study was supported by the National Natural Science Foundation of China. The researchers had no financial conflicts to disclose.

Commentary

“This systematic review of three large cohort studies enrolling 5,706,525 participants looked at risk of risk of aortic aneurysm in patients with psoriasis. I led one of these cohort studies. In our study, the hazard ratio was 1.17 with confidence intervals of 0.98 and 1.40. Even though the hazard ratio is numerically higher than 1.0, it is not significant since the confidence intervals crosses 1.

With more numbers, there is more power to find associations like these. Further, it showed that the more severe the disease, the higher the risk of aortic aneurysm. This is consistent with other comorbidities: more severe the disease, the higher the risk of the comorbidity.”

Jashin J. Wu, MD

Founder and Course Director, San Diego Dermatology Symposium, June 11-13, 2021

Founder and CEO, Dermatology Research and Education Foundation, Irvine, CA

Citation:

Yu X et al. Clin Cardiol. 2020 Jul 17. doi: 10.1002/clc.23438.