Clinical Edge

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Patients’ Characteristics and Systemic Treatments in Psoriasis

Comorbidities play a crucial role in decision-making of systemic treatments usage for psoriasis, a new study found. The retrospective analysis examined the main associations between patients’ characteristics and systemic treatments prescribed for psoriasis in a large group of patients observed in real life clinical practice. Researchers found:

  • 549 patients (mean age 46.7 years) were included in the analysis.
  • Conventional therapies like retinoids and methotrexate were associated with no previous systemic therapies for psoriasis, a moderate quality of life (QOL) at therapy onset, and older age.
  • Cyclosporine and PUVA/UVB treatments were linked to a more severe condition, including impaired QOL.
  • Comorbidities, including chronic liver or kidney diseases and tuberculosis, played a central role in decision-making of systemic treatments usage for psoriasis.


Cazzaniga S, et al. Linkage between patients’ characteristics and prescribed systemic treatments for psoriasis: a semantic connectivity map analysis of the Swiss SDNTT registry. [Published online ahead of print September 28, 2019]. J Eur Acad Dermatol Venereol. doi: 10.1111/jdv.15983.