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Emotional memory reactivation has little impact on ECT effectiveness

Key clinical point: Emotional memory reactivation prior to electroconvulsive therapy (ECT) did not improve ECT effectiveness, speed of response, or relapse rates.

Major finding: Regardless of memory intervention, 42.4% of patients responded with a ≥ 50% decrease of symptom severity.

Study details: This study was conducted in the Netherlands from 2014-2018 and involved 72 participants. Depression scores and relapse rates after 6 months were assessed using the Hamilton Depression Rating Scale (HDRS).

Disclosures: Dr Ruhé reported personal speaking fees from Lundbeck outside the submitted work. Dr van Wingen reported grants from the Brain Foundation of the Netherlands (Hersenstichting) during the conduct of the study.


Sheepens, D, et al. JAMA Netw Open. 2020;3(8):e2012389. doi:10.1001/jamanetworkopen.2020.12389