Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Even Low-Dose Steroids Increase DMARD Infection Risk

Key clinical point: Use of even low-dose steroids increases the risk of serious infections with antirheumatic drugs.

Major finding: Glucocorticoids were associated with an increased rate of serious infections even with doses at or below 5 mg/day.

Study details: A review of 170,357 Medicare patients

Disclosures: The work was funded by the National Institutes of Health. Dr. George disclosed relationships with AbbVie and Bristol-Myers Squibb.


George M et al. ACR 2019, Abstract 848.