A Zika virus vaccine of moderate to high efficacy may virtually eliminate prenatal infections through a combination of direct protection and transmission reduction, a recent study found. The study sought to quantify the effect of Zika vaccine (with 75% efficacy) prioritization of females aged 9 to 49 years, followed by males aged 9 to 49 years, on incidence of prenatal Zika infections. A compartmental model of Zika transmission between mosquitoes and humans was developed and calibrated to empirical estimates of country-specific mosquito density. 34 counties and territories in the Americans with documented Zika outbreaks were included in the analysis. Researchers found:
- For a base-case vaccine efficacy of 75% and vaccination coverage of 90%, immunizing females aged 9 to 49 years would reduce the incidence of prenatal infections by at least 94%.
- In regions where an outbreak is not expected for at least 10 years, vaccination of women aged 15 to 29 years in more efficient than that of women aged ≥30 years.
- The study was limited in that population-level modeling may not capture all local and neighborhood-level heterogeneity in mosquito abundance or Zika incidence.
Durham DP, Fitzpatrick MC, Ndeffo-Mbah ML, Parpia AS, Michael NL, Galvani AP. Evaluating vaccination strategies for Zika virus in the Americas. [Published online ahead of print April 3, 2018]. Ann Intern Med. doi:10.7326/M17-0641.
This Week's Must Reads
Do PCPs Recommend Medical Marijuana to Patients?, J Am Board Fam Med; 2018 Sep-Oct; Kondrad, et al
Intake of Sugars and Saturated Fats in US Children, Am J Clin Nutrit; ePub 2018 Sep 20; Wang, et al
Impact of Opioid Controlled Substance Agreements, Mayo Clin Proc; ePub 2018 Sep 20; Philpot, et al
MDD Screening Remains Low in Adolescents , J Pediatr; ePub 2018 Sep 21; Sekhar, et al
Subjective Wellbeing and Cardiometabolic Health, BMJ; ePub 2018 Sep 25; Wootton, et al
Must Reads in Infectious Diseases
Trends in HPV-Associated Cancers in the US, MMWR; 2018 Aug 24; Van Dyne, Henley, et al
HIV Viral Suppression Trends in the US, Ann Intern Med; ePub 2018 Aug 21; Nance, et al
Antibiotic Use Among US Older Adults, BMJ; ePub 2018 Jul 27; Olesen, Barnett, et al
Antiretroviral Drugs for Management of HIV, JAMA; 2018 Jul 24/31; Saag, Benson, et al
Global Burden of CVD in People Living with HIV, Circulation; ePub 2018 Jul 2; Shah, et al