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Muscular Strength and Incidence of Type 2 Diabetes

Mayo Clin Proc; ePub 2019 Mar 11; Wang, et al

In a large cohort study of adult patients with no diabetes at baseline, a moderate level of muscular strength was associated with a lower risk of type 2 diabetes (T2D), independent of estimated cardiorespiratory fitness (CRF). A total of 4,681 adults aged 20‒100 years underwent muscular strength tests and maximal treadmill exercise tests between January 1, 1981, and December 31, 2006. Among the findings:

  • During a mean follow-up of 8.3 years, 229 of 4,681 participants (4.9%) had development of T2D.
  • Those with the middle level of muscular strength had a 32% lower risk of development of T2D compared with those with the lower level of muscular strength.
  • There was no significant association between the upper level of muscular strength and incident T2D.


Wang Y, Lee D, Brellenthin AG, et al. Association of muscular strength and incidence of type 2 diabetes. [Published online ahead of print March 11, 2019]. Mayo Clin Proc. doi:10.1016/j.mayocp.2018.08.037.