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Insulin Resistance Associated With Depression

Key clinical point: Insulin resistance is associated with depression and cognitive dysfunction, but also with verbal intelligence.

Major finding: The presence of depression, as well as verbal intelligence, was positively associated with the polygenic risk score for fasting insulin, and significant associations were found between depression and the PRS for homeostasis model assessment of insulin resistance.

Study details: The data come from a study of two population-based cohorts: Generation Scotland: The Scottish Family Health Study (19,994 individuals), and the U.K. Biobank (331,374 individuals).

Disclosures: The researchers had no financial conflicts to disclose.


Frangou S et al. Exp Neurol. 2019. doi: 10.1016/j.expneurol.2019.04.001