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High Cortisol, Inflammation Tied to Persistent Depressive Symptoms

Key clinical point: Elevated hair cortisol and plasma C-reactive protein (CRP) levels were associated with persistent depressive symptoms in older adults and were more strongly related to somatic symptoms than to cognitive-affective symptoms.

Major finding: About 16% of the patients in the cortisol sample group and 14% of those in the CRP sample groups met criteria for high depressive symptoms, based on Centre for Epidemiological Studies-Depression scores of 3 and higher.

Study details: The data come from a population-based, 14-year study including 4,761 adults aged 50 and older who were participating in the English Longitudinal Study of Ageing.

Disclosures: The researchers disclosed no financial conflicts.


Iob E et al. Mol Psychiatry 2019. doi: 10.1038/s41380-019-0501-6