Key clinical point: Depressive symptomatology was associated with DNA methylation of genes involved in stress response, depressive behaviors, and recurrent depression.
Major finding: The researchers identified the cg00554948 probe on chromosome 12 as the most significant finding related to the impact of DNA methylation age on depression.
Study details: The data come from a study of 724 Danish monozygotic twins (362 complete twin pairs; 378 women, 346 men) who were participating in the Middle-Aged Danish Twin Study and the Longitudinal Study of Aging in Danish Twins.
Disclosures: The study was funded by the Danish Council for Independent Research, the European Union’s Seventh Framework Programme, and the Lundbeck Foundation, Denmark. The researchers had no financial conflicts.
Starnawska A et al. Transl Psychiatry. 2019. doi: 10.1038/s41398-019-0548-9