Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Diabetes and Depression Increase Mortality Risk

Key clinical point: The coexistence of diabetes and depressive symptoms in older adults is associated with the highest mortality risk in this population, moderated by inflammatory status.

Major finding: Participants with both diabetes and depression had higher mortality risk (hazard ratio [HR] 2.33) than those with each condition alone (HR diabetes: 2.08; HR depression: 1.26). High level of hs-CRP significantly moderated the risk of mortality in those with both diabetes and depression.

Study details: An analysis of 1,183 community-dwelling older adults divided into 4 groups and followed-up for a median of 13.5 years.


Castro-Costa E, et al. Depress Anxiety. 2019 May 8. doi: 10.1002/da.22908.