Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Transient Opioid Use Linked to COPD Exacerbation

Key clinical point: Short-term opioid use is associated with acute respiratory exacerbation in adults with COPD.

Major finding: Opioid exposure in the prior 7 days was associated with an 80.8% increase in the odds of exacerbation (odds ratio, 1.81; 95% confidence interval, 1.60-2.05).

Study details: Analysis of Mississippi Medicaid administrative claims data including 1,354 beneficiaries and 1,972 exacerbation events

Disclosures: There was no funding for this study, and none of the researchers declared conflicts of interest.


Rong Y et al. Am J Epidemiol. 2019 Jul 30. doi: 10.1093/aje/kwz169.