Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

CKD-MBD Clinical Practice Guideline Update

Ann Intern Med; ePub 2018 Feb 20; Ketteler, et al

The Kidney Disease: Improving Global Outcomes (KDIGO) 2017 clinical practice guideline update for the diagnosis, evaluation, prevention, and treatment of chronic kidney disease –mineral and bone disorder (CKD-MBD) is intended to assist practitioners caring for adults with CKD and those receiving long-term dialysis. The update includes the revision of 15 recommendations. This synopsis focuses primary on:

  • Recommendations for diagnosis and treatment of CKD-MBD that emphasizes decreasing phosphate levels, maintaining calcium levels, and addressing elevated parathyroid hormone levels in adults with CKD state G3a to G5 and those receiving dialysis.
  • Key elements include basing treatment or trends in laboratory values rather than in a single abnormal result and being cautious to avoid hypercalcemia when treating secondary hyperparathyroidism.

The complete 2017 update is available at www.kdigo.org.

Citation:

Ketteler M, Block GA, Evenepoel P, et al. Diagnosis, evaluation, prevention, and treatment of chronic kidney disease–mineral and bone disorder: Synopsis of the Kidney Disease: Improving Global Outcomes 2017 Clinical Practice Guideline update. Ann Intern Med. [Published online ahead of print February 20, 2018]. doi:10.7326/M17-2640.

This Week's Must Reads

Is Obesity Associated With Adverse CV Outcomes?, JAMA Netw Open; 2018 Nov 16; Riaz, et al

BMI & Risk of Postpregnancy T2D in Women with HDP , Diabetes Care; ePub 2018 Nov 19; Timpka, et al

Diabetes Outcomes in Patients by PCPs, NPs, or PAs, Ann Intern Med; ePub 2018 Nov 20; Jackson, et al

Traumatic Exposures & Health Issues in Older Women, JAMA Intern Med; ePub 2018 Nov 19; Gibson, et al

Risk of Opioid Overdose Hospitalizations , J Am Board Fam Med; 2018 Nov-Dec; Peters, et al

Must Reads in Nephrology

Kidney Damage Biomarkers & Incident CKD in BP Reduction, Ann Intern Med; ePub 2018 Oct 23; Zhang, et al

Prescription NSAID Use in High-Risk Patients, JAMA Intern Med; ePub 2018 Oct 8; Bouck, et al

Metformin Use and Hospitalization with Acidosis, JAMA Intern Med; 2018 Jul; Lazarus, et al

Diabetes & Long-Term Kidney Disease, Diabetes Care; ePub 2018 Jun 1; Warren, et al

CKD-MBD Clinical Practice Guideline Update, Ann Intern Med; ePub 2018 Feb 20; Ketteler, et al