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Is Obesity Associated With Adverse CV Outcomes?

JAMA Netw Open; 2018 Nov 16; Riaz, et al

Obesity is associated with type 2 diabetes (T2D) and coronary artery disease (CAD), but not with stroke, according to a systematic review and meta-analysis of nearly 1 million participants. Studies that used mendelian randomization methods to assess the association between any measure of obesity and the incidence of cardiovascular (CV) events and those that reported odds ratios (ORs) with 95% CIs estimated using an instrumental variable method were included. 5 studies were included in the final analysis. Researchers found:

  • Of 4,660 potentially relevant articles, 2,511 titles were screened; 7 were included in the systematic review, and 5 with 881,692 participants were eligible for inclusion in the meta-analysis.
  • Obesity was significantly associated with an increased risk of T2D (OR, 1.67) and CAD (OR, 1.20).
  • However, no association between obesity and stroke was found (OR, 1.02).

Citation:

Riaz H, Khan MS, Siddiqi TJ, et al. Association between obesity and cardiovascular outcomes. A systematic review and meta-analysis of mendelian randomization studies. JAMA Netw Open. 2018;1(7):e183788. doi:10.1001/jamanetworkopen.2018.3788.

This Week's Must Reads

Is Obesity Associated With Adverse CV Outcomes?, JAMA Netw Open; 2018 Nov 16; Riaz, et al

BMI & Risk of Postpregnancy T2D in Women with HDP , Diabetes Care; ePub 2018 Nov 19; Timpka, et al

Diabetes Outcomes in Patients by PCPs, NPs, or PAs, Ann Intern Med; ePub 2018 Nov 20; Jackson, et al

Traumatic Exposures & Health Issues in Older Women, JAMA Intern Med; ePub 2018 Nov 19; Gibson, et al

Risk of Opioid Overdose Hospitalizations , J Am Board Fam Med; 2018 Nov-Dec; Peters, et al

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Is Obesity Associated With Adverse CV Outcomes?, JAMA Netw Open; 2018 Nov 16; Riaz, et al

Cholesterol Guidelines Stress Lifetime Approach, Circulation; ePub 2018 Nov 10; Grundy, et al

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Elevated BP in Young Adults & Subsequent CVD Risk, JAMA; 2018 Nov 6; Yano, Reis, et al

Health Literacy and 1-Year Mortality in CVD, Mayo Clin Proc; ePub 2018 Nov 7; Mayberry, et al