Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Is Obesity Associated With Adverse CV Outcomes?

JAMA Netw Open; 2018 Nov 16; Riaz, et al

Obesity is associated with type 2 diabetes (T2D) and coronary artery disease (CAD), but not with stroke, according to a systematic review and meta-analysis of nearly 1 million participants. Studies that used mendelian randomization methods to assess the association between any measure of obesity and the incidence of cardiovascular (CV) events and those that reported odds ratios (ORs) with 95% CIs estimated using an instrumental variable method were included. 5 studies were included in the final analysis. Researchers found:

  • Of 4,660 potentially relevant articles, 2,511 titles were screened; 7 were included in the systematic review, and 5 with 881,692 participants were eligible for inclusion in the meta-analysis.
  • Obesity was significantly associated with an increased risk of T2D (OR, 1.67) and CAD (OR, 1.20).
  • However, no association between obesity and stroke was found (OR, 1.02).

Citation:

Riaz H, Khan MS, Siddiqi TJ, et al. Association between obesity and cardiovascular outcomes. A systematic review and meta-analysis of mendelian randomization studies. JAMA Netw Open. 2018;1(7):e183788. doi:10.1001/jamanetworkopen.2018.3788.

This Week's Must Reads

Intensive BP Control & Risk of Dementia, JAMA; ePub 2019 Jan 28; SPRINT MIND Investigators

Outpatient Care for Adults With Primary Care, JAMA Intern Med; ePub 2019 Jan 28; Levine, et al

Antibiotic Therapy in Patients with Asthma, JAMA Intern Med; ePub 2019 Jan 28; Stefan, et al

Outpatient Benzodiazepine Prescribing in US, JAMA Netw Open; 2019 Jan 25; Agarwal, et al

Reduction of Readmissions Through Primary Care, JAMA Netw Open; 2019 Jan 25; Wiest, et al

Must Reads in Cardiology

Intensive BP Control & Risk of Dementia, JAMA; ePub 2019 Jan 28; SPRINT MIND Investigators

Aspirin for Prevention of CV Events, JAMA; 2019 Jan 22; Zheng, Roddick

Educational Attainment & CV Risk in Hispanic Persons, JAMA Cardiol; 2019 Jan; Rodriguez, Leonard, et al

Long-Term Absolute Risk for CVD by FG Level, Diabetes Care; ePub 2019 Jan 7; Bancks, et al

Do Vitamin D Supplements Prevent Cancer, CVD?, N Engl J Med; 2019 Jan 3; Manson, Cook, et al