Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Collaborative Care vs Usual Care in Heart Failure

JAMA Intern Med; ePub 2018 Feb 26; Bekelman, et al

Among patients with chronic heart failure (HF), a symptom and psychosocial collaborative care intervention was not significantly better than usual care for improving HF–specific health status, a recent study found. In the single-blind, 2-arm, multisite randomized clinical trial, 314 patients were randomized to receive the Collaborative Care to Alleviate Symptoms and Adjust to Illness (CASA) intervention or usual care. The CASA intervention included collaborative symptom care provided by a nurse and psychosocial care provided by a social worker, both of whom worked with the patients’ primary care clinicians and were supervised by a study primary care clinician, cardiologist, and palliative care physician. Researchers found:

  • The primary outcome of HF–specific health status did not change with the intervention.
  • Among secondary outcomes, depressive symptoms and fatigue improved with the intervention, but pain and shortness of breath did not.
  • Mortality at 12 months was similar in both arms.


Bekelman DB, Allen LA, McBryde CF, et al. Effect of a collaborative care intervention vs usual care on health status of patients with chronic heart failure. The CASA randomized clinical trial. [Published online ahead of print February 26, 2018]. JAMA Intern Med. doi:10.1001/jamainternmed.2017.8667.

This Week's Must Reads

Screening for Syphilis Infection in Pregnant Women, JAMA; 2018 Sep 4; US Preventive Services Task Force

Treatment Intensification Guidelines for T2D , Ann Intern Med; ePub 2018 Sep 4; Roglic, et al

Immediate vs Gradual Nicotine Reduction in Cigarettes, JAMA; ePub 2018 Sep 4; Hatsukami, et al

Prevalence of Diabetes Among US Adults, BMJ; ePub 2018 Aug 27; Xu, Liu, et al

Effect of Fish Oil Supplementation in Pregnancy, BMJ; ePub 2018 Sep 4; Vinding, Stokholm, et al

Must Reads in Cardiology

Aspirin for Primary CV Prevention in Diabetes, N Engl J Med; ePub 2018 Aug 26; ASCEND Study Collaborative Group

CV Mortality Among Adults with Diabetes, Diabetes Care; ePub 2018 Aug 21; Cheng, et al

Does Dietary Diversity Promote a Healthy Weight?, Circulation; ePub 2018 Aug 9; de Oliveira, et al

USPSTF: Recommendation in Screening for AF, JAMA; 2018 Aug 7; US Preventive Services Task Force

Contemporary Management of Patients with PE, Am J Med; ePub 2018 Aug 10; Secemsky, et al