Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Aspirin for Primary CV Prevention in Diabetes

N Engl J Med; ePub 2018 Aug 26; ASCEND Study Collaborative Group

In adults with diabetes mellitus (DM), aspirin use prevented serious vascular events but also caused major bleeding events, a recent study found. Researchers randomly assigned adults who had diabetes but no evident cardiovascular (CV) disease to receive aspirin (100 mg daily) or matching placebo. The primary efficacy outcome was the first serious vascular event and the primary safety outcome was the first major bleeding events. Secondary outcomes included gastrointestinal tract cancer. Among the findings:

  • 15,480 participants underwent randomization.
  • During a mean follow-up of 7.4 years, serious vascular events occurred in a significantly lower percentage of those in the aspirin group vs the placebo group (658 vs 743; rate ratio, 0.88).
  • Major bleeding events occurred in 314 (4.1%) participants in the aspirin group vs 245 (3.2%) in the placebo group (rate ratio, 1.29); most of the excess being gastrointestinal bleeding and other extracranial bleeding.
  • There was no significant difference between groups in the incidence of gastrointestinal tract cancer.

Citation:

The ASCEND Study Collaborative Group. Effects of aspirin for primary prevention in persons with diabetes mellitus. [Published online ahead of print August 26, 2018]. N Engl J Med. doi:10.1056/NEJMoa1804988.

This Week's Must Reads

Elevated BP in Young Adults & Subsequent CVD Risk, JAMA; 2018 Nov 6; Yano, Reis, et al

Health Literacy and 1-Year Mortality in CVD, Mayo Clin Proc; ePub 2018 Nov 7; Mayberry, et al

Paternal Age and Perinatal Outcomes in the US, BMJ; ePub 2018 Oct 31; Khandwala, et al

Healthcare-Associated Infections in US Hospitals, N Engl J Med; 2018 Nov 1; Magill, O’Leary, et al

Early Antibiotic Use & Weight Outcomes in Children, Pediatrics; ePub 2018 Oct 31; Block, Bailey, et al

Must Reads in Cardiology

Elevated BP in Young Adults & Subsequent CVD Risk, JAMA; 2018 Nov 6; Yano, Reis, et al

Health Literacy and 1-Year Mortality in CVD, Mayo Clin Proc; ePub 2018 Nov 7; Mayberry, et al

Treating Low-Risk Patients with Mild Hypertension, JAMA Intern Med; ePub 2018 Oct 29; Sheppard, et al

Concomitant DOAC-Antiplatelet Use & Bleeding Risk, Am J Med; ePub 2018 Oct 25; Douros, et al

Omega 3 Polyunsaturated Fatty Acids & Healthy Aging, BMJ; ePub 2018 Oct 17; Lai, Otto, et al