Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Aspirin Benefit in Adverse Pregnancy Outcomes

Hypertension; ePub 2018 May 25; Hauspurg, et al

The presence of stage 1 hypertension is associated with a significantly increased risk of preeclampsia when compared with high-risk normotensive women; however, this risk was significantly reduced with aspirin treatment. This according to a secondary analysis of the high-risk aspirin trial that included women with prior preeclampsia or diabetes mellitus (DM). Among the findings:

  • 827 (81%) women were classified as normotensive; 193 (19%) were classified as stage 1 hypertensive.
  • Among women receiving placebo, preeclampsia occurred significantly more often in women with state 1 hypertension compared with normotensive high-risk women after adjustment for maternal age and body mass index (BMI).
  • Moreover, women with stage 1 hypertension had a significant risk reduction related to aspirin prophylaxis (risk ratio, 0.61) not seen in normointensive high-risk women.


Hauspurg A, Sutton EF, Catov JM, Caritis SN. Aspirin effect on adverse pregnancy outcomes associated with stage 1 hypertension in a high-risk cohort. [Published online ahead of print May 25, 2018]. Hypertension. doi:10.1161/HYPERTENSIONAHA.118.11196.

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