Key clinical point: Exposure to opioids in utero was significantly associated with poor outcomes, including small for gestational age and preterm birth, and later behavioral and development problems in young children.
Major finding: Maternal opioid exposure was associated with small for gestational age (OR 1.87) and preterm birth (OR 1.49). School-aged children with prenatal opioid exposure had an increased risk of ADHD (OR 2.55).
Study details: The data come from a cohort study of 8,509 mother/newborn pairs from a single center.
Disclosures: The Boston Birth Cohort study is supported in part by grants from the National Institutes of Health and the U.S. Department of Health and Human Services. None of the authors had financial conflicts to disclose.
Azuine RE et al. JAMA Network Open. 2019. doi: 10.1001/jamanetworkopen.2019.6405.