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Cathepsin Z identified as a potential biomarker for osteoporosis

Key clinical point: There was an increase in levels of cathepsin Z mRNA in peripheral blood mononuclear cells in participants with osteopenia and osteoporosis, compared with nonosteoporotic controls.

Major finding: Cathepsin Z was inversely associated with bone mineral density and inversely associated with lumbar spine L2-L4 and femoral neck T scores in participants with osteopenia, osteoporosis, and women with osteoporosis who were older than 50 years.

Study details: An analysis of cathepsin Z mRNA levels in PBMC samples from 88 participants with osteopenia, osteoporosis, and no osteoporosis.

Disclosures: The authors reported no relevant conflicts of interest.


Dera AA et al. Sci Rep. 2019 Jul 5. doi: 10.1038/s41598-019-46068-0.